Endocrine Abstracts

Background: Chronic anovulation constitutes one of the cardinal features of Polycystic Ovary Syndrome (PCOS) and Anti-Müllerian hormone (AMH), a granulosa cell product, is a well documented marker of anovulation. Recent data have shown that oxidative stress is involved in the pathophysiology of anovulation. A marker of oxidative stress, Advanced Glycosylated End products (AGEs), is implicated to the pathogenesis of the syndrome and have been localized with high intensity ...

Background: Polycystic ovary syndrome (PCOS) is associated with obesity and insulin resistance, two major contributors to cardiovascular risk. Even in the absence of detectable insulin resistance, lean, non-diabetic PCOS women demonstrate increased circulating levels of advanced glycated end products (AGEs), known proatherogenic molecules. This adverse cardiovascular risk profile should be considered in the syndrome’s management.Objective: To invest...